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Dr. Shivani Sachdev Gour exlpain about Vitrification at Surrogacy Centre India (SCI Healthcare)

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Dr. Shivani Sachdev Gour exlpain about Vitrification at Surrogacy Centre India (SCI Healthcare) Empty Dr. Shivani Sachdev Gour exlpain about Vitrification at Surrogacy Centre India (SCI Healthcare)

Post  mirage Tue Sep 24, 2013 3:18 am

Dr. Shivani Sachdev gour explains Vitrification:---

This is a process by which an embryo is maintained for long time in a state of stand still, till the conditions are favourable for implantation. Vitrification literally means “glass like transitional” status of a substance.  When a liquid is cooled rapidly it reaches a glass like state. The molecules are loosely bonded using “thermal” bonds. When the temperature increases it again becomes liquid. It is used in glass industry and various chemical industries. It is used in nuclear plants to fix and dispose radioactive wastes. In the field of medicine it refers to preservation of sperm, egg or embryo.   It is useful in patients


  • Undergoing radiotherapy or cancer chemotherapy to preserve fertility
  • Who have lost their uterus or uterus is absent/ abnormal by birth (MRKH Syndrome)
  • Who had recurrent IVF failures and plan for surrogacy
  • Any genetic defects where PGD is to be used (embryos are preserved till reports are available)
  • Excess embryos in a cycle – for use in succeeding cycle.
  • The process may involve embryos made from parents or donors.

Freezing is being used to preserve sperms, oocytes and embryos. Sperm freezing was done first, it is easier and most successful and regularly used. Oocyte freezing is very challenging and most difficult. Embryo (fertilized egg) freezing is relatively easier and is more commonly used. The main problem in cryopreservation or vitrification is ice crystal formation. While water is essential part of the cell, ice crystals are not and they destroy the cell structure. The sperm has minimal water content, so minimal ice crystal formation and easier to preserve. The oocyte has lot of water and easily forms ice crystals – hence most difficult to preserve. When a young or unmarried person needs preservation before radio or chemotherapy, the options available till now were ovarian tissue preservation or fertilizing the oocytes with donor sperm and then cryopreserving the embryos. Now days with advancements in anti- freeze liquids, the hope for oocyte preservation has increased.

There are two main types of egg freezing: Slow and Rapid methods.

In Slow method:--  The main aim is to remove most of the water from the oocyte without damaging it, so that ice crystal formation is minimised. But all the water cannot be removed, and some crystal still forms. Hence the quantity and quality of the oocyte after thawing is poor.

In Rapid freezing (Vitrification) Method:-- The main aim is to freeze the oocytes so fast that ice crystals do not have time to form. This involves the use of an anti- freeze chemical that allows rapid cooling. But this chemical is potentially toxic to the oocyte; hence the egg should be exposed only for a minimal time and very carefully to avoid chemical injury to the egg. The thawing should also be equally quick and the fertilization should be preferably by ICSI and may need laser hatching as the zona becomes thickened during vitrification (see previous blogs on thick zona and laser hatching).

This method is currently used for young and single persons undergoing cancer treatments, radiotherapy and chemotherapy. Some centres are promoting this method to delay parenthood without having to worry about age-related “ageing” effects – infertility, genetic defects etc.

Website:-- surrogacycentreindia.com

mirage

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Join date : 2013-09-24

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